Regenerating Urethral Striated Muscle by CRISPRi/dCas9-KRAB-Mediated Myostatin Silencing for Obesity-Associated Stress Urinary Incontinence

Overweight females are prone to obesity-associated stress urinary incontinence (OA-SUI), and there are no definitive medical therapies for this common urologic condition. This study was designed to test the hypothesis that regenerative therapy to restore urethral striated muscle (stM) and pelvic flo...

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Библиографические подробности
Опубликовано в: :CRISPR J
Главные авторы: Yuan, Huixing, Ruan, Yajun, Tan, Yan, Reed-Maldonado, Amanda B., Chen, Yinwei, Zhao, Dehua, Wang, Zhao, Zhou, Feng, Peng, Dongyi, Banie, Lia, Wang, Guifang, Liu, Jihong, Lin, Guiting, Qi, Lei S., Lue, Tom F.
Формат: Artigo
Язык:Inglês
Опубликовано: Mary Ann Liebert, Inc., publishers 2020
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Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7757699/
https://ncbi.nlm.nih.gov/pubmed/33346712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/crispr.2020.0077
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