Regenerating Urethral Striated Muscle by CRISPRi/dCas9-KRAB-Mediated Myostatin Silencing for Obesity-Associated Stress Urinary Incontinence

Overweight females are prone to obesity-associated stress urinary incontinence (OA-SUI), and there are no definitive medical therapies for this common urologic condition. This study was designed to test the hypothesis that regenerative therapy to restore urethral striated muscle (stM) and pelvic flo...

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Vydáno v:CRISPR J
Hlavní autoři: Yuan, Huixing, Ruan, Yajun, Tan, Yan, Reed-Maldonado, Amanda B., Chen, Yinwei, Zhao, Dehua, Wang, Zhao, Zhou, Feng, Peng, Dongyi, Banie, Lia, Wang, Guifang, Liu, Jihong, Lin, Guiting, Qi, Lei S., Lue, Tom F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc., publishers 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7757699/
https://ncbi.nlm.nih.gov/pubmed/33346712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/crispr.2020.0077
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