Regenerating Urethral Striated Muscle by CRISPRi/dCas9-KRAB-Mediated Myostatin Silencing for Obesity-Associated Stress Urinary Incontinence

Overweight females are prone to obesity-associated stress urinary incontinence (OA-SUI), and there are no definitive medical therapies for this common urologic condition. This study was designed to test the hypothesis that regenerative therapy to restore urethral striated muscle (stM) and pelvic flo...

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Detalhes bibliográficos
Publicado no:CRISPR J
Main Authors: Yuan, Huixing, Ruan, Yajun, Tan, Yan, Reed-Maldonado, Amanda B., Chen, Yinwei, Zhao, Dehua, Wang, Zhao, Zhou, Feng, Peng, Dongyi, Banie, Lia, Wang, Guifang, Liu, Jihong, Lin, Guiting, Qi, Lei S., Lue, Tom F.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7757699/
https://ncbi.nlm.nih.gov/pubmed/33346712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/crispr.2020.0077
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