Regenerating Urethral Striated Muscle by CRISPRi/dCas9-KRAB-Mediated Myostatin Silencing for Obesity-Associated Stress Urinary Incontinence

Overweight females are prone to obesity-associated stress urinary incontinence (OA-SUI), and there are no definitive medical therapies for this common urologic condition. This study was designed to test the hypothesis that regenerative therapy to restore urethral striated muscle (stM) and pelvic flo...

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Bibliographic Details
Published in:CRISPR J
Main Authors: Yuan, Huixing, Ruan, Yajun, Tan, Yan, Reed-Maldonado, Amanda B., Chen, Yinwei, Zhao, Dehua, Wang, Zhao, Zhou, Feng, Peng, Dongyi, Banie, Lia, Wang, Guifang, Liu, Jihong, Lin, Guiting, Qi, Lei S., Lue, Tom F.
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc., publishers 2020
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7757699/
https://ncbi.nlm.nih.gov/pubmed/33346712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/crispr.2020.0077
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