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Microglial phagocytosis dysfunction in the dentate gyrus is related to local neuronal activity in a genetic model of epilepsy

OBJECTIVE: Microglial phagocytosis of apoptotic cells is an essential component of the brain regenerative response during neurodegeneration. Whereas it is very efficient in physiological conditions, it is impaired in mouse and human mesial temporal lobe epilepsy, and now we extend our studies to a m...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Epilepsia
Hauptverfasser: Sierra‐Torre, Virginia, Plaza‐Zabala, Ainhoa, Bonifazi, Paolo, Abiega, Oihane, Díaz‐Aparicio, Irune, Tegelberg, Saara, Lehesjoki, Anna‐Elina, Valero, Jorge, Sierra, Amanda
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756777/
https://ncbi.nlm.nih.gov/pubmed/32940364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.16692
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