A Novel Prodrug of a nNOS Inhibitor with Improved Pharmacokinetic Potential

Under different pathological conditions, aberrant induction of neuronal nitric oxide synthase (nNOS) generates overproduction of NO that can cause irreversible cell damage. The aim of this study was to develop an amidoxime prodrug of a potent nNOS inhibitor, the benzhydryl acetamidine. We synthesize...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ChemMedChem
Prif Awduron: Maccallini, Cristina, Marinelli, Lisa, Indorf, Patrick, Cacciatore, Ivana, Fantacuzzi, Marialuigia, Clement, Bernd, Di Stefano, Antonio, Amoroso, Rosa
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2020
Pynciau:
Full Papers
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756445/
https://ncbi.nlm.nih.gov/pubmed/32783298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000349
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