A Novel Prodrug of a nNOS Inhibitor with Improved Pharmacokinetic Potential

Under different pathological conditions, aberrant induction of neuronal nitric oxide synthase (nNOS) generates overproduction of NO that can cause irreversible cell damage. The aim of this study was to develop an amidoxime prodrug of a potent nNOS inhibitor, the benzhydryl acetamidine. We synthesize...

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Publicado en:ChemMedChem
Autores principales: Maccallini, Cristina, Marinelli, Lisa, Indorf, Patrick, Cacciatore, Ivana, Fantacuzzi, Marialuigia, Clement, Bernd, Di Stefano, Antonio, Amoroso, Rosa
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756445/
https://ncbi.nlm.nih.gov/pubmed/32783298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000349
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