A Novel Prodrug of a nNOS Inhibitor with Improved Pharmacokinetic Potential

Under different pathological conditions, aberrant induction of neuronal nitric oxide synthase (nNOS) generates overproduction of NO that can cause irreversible cell damage. The aim of this study was to develop an amidoxime prodrug of a potent nNOS inhibitor, the benzhydryl acetamidine. We synthesize...

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Veröffentlicht in:ChemMedChem
Hauptverfasser: Maccallini, Cristina, Marinelli, Lisa, Indorf, Patrick, Cacciatore, Ivana, Fantacuzzi, Marialuigia, Clement, Bernd, Di Stefano, Antonio, Amoroso, Rosa
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756445/
https://ncbi.nlm.nih.gov/pubmed/32783298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000349
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