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Genomics‐Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism

A gene cluster encoding a cryptic trans‐acyl transferase polyketide synthase (PKS) was identified in the genomes of Burkholderia gladioli BCC0238 and BCC1622, both isolated from the lungs of cystic fibrosis patients. Bioinfomatics analyses indicated the PKS assembles a novel member of the glutarimid...

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Bibliografische gegevens
Gepubliceerd in:Angew Chem Int Ed Engl
Hoofdauteurs: Nakou, Ioanna T., Jenner, Matthew, Dashti, Yousef, Romero‐Canelón, Isolda, Masschelein, Joleen, Mahenthiralingam, Eshwar, Challis, Gregory L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756379/
https://ncbi.nlm.nih.gov/pubmed/32918852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202009007
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