A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis

Polyketide synthases assemble diverse natural products with numerous important applications. The thioester intermediates in polyketide assembly are covalently tethered to acyl carrier protein domains of the synthase. Several mechanisms for polyketide chain release are known, contributing to natural...

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Bibliografske podrobnosti
izdano v:Nat Chem
Main Authors: Masschelein, Joleen, Sydor, Paulina K., Hobson, Christian, Howe, Rhiannon, Jones, Cerith, Roberts, Douglas M., Ling Yap, Zhong, Parkhill, Julian, Mahenthiralingam, Eshwar, Challis, Gregory L.
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774797/
https://ncbi.nlm.nih.gov/pubmed/31548673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-019-0309-7
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