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A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis

Polyketide synthases assemble diverse natural products with numerous important applications. The thioester intermediates in polyketide assembly are covalently tethered to acyl carrier protein domains of the synthase. Several mechanisms for polyketide chain release are known, contributing to natural...

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Bibliografiska uppgifter
I publikationen:Nat Chem
Huvudupphovsmän: Masschelein, Joleen, Sydor, Paulina K., Hobson, Christian, Howe, Rhiannon, Jones, Cerith, Roberts, Douglas M., Ling Yap, Zhong, Parkhill, Julian, Mahenthiralingam, Eshwar, Challis, Gregory L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774797/
https://ncbi.nlm.nih.gov/pubmed/31548673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-019-0309-7
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