Systems approach to metal-based pharmacology

Por Romero-Canelón, Isolda, Sadler, Peter J.
Publicado no Proc Natl Acad Sci U S A (2015)

Enhancement of Selectivity of an Organometallic Anticancer Agent by Redox Modulation

Por Romero-Canelón, Isolda, Mos, Magdalena, Sadler, Peter J.
Publicado no J Med Chem (2015)

Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design

Por Soldevila-Barreda, Joan J., Romero-Canelón, Isolda, Habtemariam, Abraha, Sadler, Peter J.
Publicado no Nat Commun (2015)

Potent Half-Sandwich Iridium(III) Anticancer Complexes Containing C(∧)N-Chelated and Pyridine Ligands

Por Liu, Zhe, Romero-Canelón, Isolda, Habtemariam, Abraha, Clarkson, Guy J., Sadler, Peter J.
Publicado em 2014

Comparative Cytotoxicity of Artemisinin and Cisplatin and Their Interactions with Chlorogenic Acids in MCF7 Breast Cancer Cells

Por Suberu, John O, Romero-Canelón, Isolda, Sullivan, Neil, Lapkin, Alexei A, Barker, Guy C
Publicado no ChemMedChem (2014)

Contrasting Anticancer Activity of Half-Sandwich Iridium(III) Complexes Bearing Functionally Diverse 2-Phenylpyridine Ligands

Por Millett, Adam J., Habtemariam, Abraha, Romero-Canelón, Isolda, Clarkson, Guy J., Sadler, Peter J.
Publicado no Organometallics (2015)

Organometallic Iridium(III) Anticancer Complexes with New Mechanisms of Action: NCI-60 Screening, Mitochondrial Targeting, and Apoptosis

Por Hearn, Jessica M., Romero-Canelón, Isolda, Qamar, Bushra, Liu, Zhe, Hands-Portman, Ian, Sadler, Peter J.
Publicado em 2013

Correction to Organometallic Iridium(III) Anticancer Complexes with New Mechanisms of Action: NCI-60 Screening, Mitochondrial Targeting, and Apoptosis

Por Hearn, Jessica M., Romero-Canelon, Isolda, Qamar, Bushra, Liu, Zhe, Hands-Portman, Ian, Sadler, Peter J.
Publicado em 2013

Synchrotron X‐Ray Fluorescence Nanoprobe Reveals Target Sites for Organo‐Osmium Complex in Human Ovarian Cancer Cells

Por Sanchez‐Cano, Carlos, Romero‐Canelón, Isolda, Yang, Yang, Hands‐Portman, Ian J., Bohic, Sylvain, Cloetens, Peter, Sadler, Peter J.
Publicado no Chemistry (2017)

Half-Sandwich Arene Ruthenium(II) and Osmium(II) Thiosemicarbazone Complexes: Solution Behavior and Antiproliferative Activity

Por Gatti, Anna, Habtemariam, Abraha, Romero-Canelón, Isolda, Song, Ji-Inn, Heer, Bindy, Clarkson, Guy J., Rogolino, Dominga, Sadler, Peter J., Carcelli, Mauro
Publicado no Organometallics (2018)

Photoactivatable Cell-Selective Dinuclear trans-Diazidoplatinum(IV) Anticancer Prodrugs

Por Shi, Huayun, Romero-Canelón, Isolda, Hreusova, Monika, Novakova, Olga, Venkatesh, V., Habtemariam, Abraha, Clarkson, Guy J., Song, Ji-inn, Brabec, Viktor, Sadler, Peter J.
Publicado no Inorg Chem (2018)

The Potent Oxidant Anticancer Activity of Organoiridium Catalysts**

Por Liu, Zhe, Romero-Canelón, Isolda, Qamar, Bushra, Hearn, Jessica M, Habtemariam, Abraha, Barry, Nicolas P E, Pizarro, Ana M, Clarkson, Guy J, Sadler, Peter J
Publicado no Angew Chem Int Ed Engl (2014)

In Vivo Selectivity and Localization of Reactive Oxygen Species (ROS) Induction by Osmium Anticancer Complexes That Circumvent Platinum Resistance

Por Coverdale, James P. C., Bridgewater, Hannah E., Song, Ji-Inn, Smith, Nichola A., Barry, Nicolas P. E., Bagley, Ian, Sadler, Peter J., Romero-Canelón, Isolda
Publicado no J Med Chem (2018)

Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells

Por Hearn, Jessica M., Romero-Canelón, Isolda, Munro, Alison F., Fu, Ying, Pizarro, Ana M., Garnett, Mathew J., McDermott, Ultan, Carragher, Neil O., Sadler, Peter J.
Publicado no Proc Natl Acad Sci U S A (2015)

In‐Cell Activation of Organo‐Osmium(II) Anticancer Complexes

Por Needham, Russell J., Sanchez‐Cano, Carlos, Zhang, Xin, Romero‐Canelón, Isolda, Habtemariam, Abraha, Cooper, Margaret S., Meszaros, Levente, Clarkson, Guy J., Blower, Philip J., Sadler, Peter J.
Publicado no Angew Chem Int Ed Engl (2016)

Transfer Hydrogenation and Antiproliferative Activity of Tethered Half-Sandwich Organoruthenium Catalysts

Por Chen, Feng, Romero-Canelón, Isolda, Soldevila-Barreda, Joan J., Song, Ji-Inn, Coverdale, James P. C., Clarkson, Guy J., Kasparkova, Jana, Habtemariam, Abraha, Wills, Martin, Brabec, Viktor, Sadler, Peter J.
Publicado no Organometallics (2018)

New activation mechanism for half-sandwich organometallic anticancer complexes

Por Banerjee, Samya, Soldevila-Barreda, Joan J., Wolny, Juliusz A., Wootton, Christopher A., Habtemariam, Abraha, Romero-Canelón, Isolda, Chen, Feng, Clarkson, Guy J., Prokes, Ivan, Song, Lijiang, O'Connor, Peter B., Schünemann, Volker, Sadler, Peter J.
Publicado no Chem Sci (2018)

Mitochondria-targeted spin-labelled luminescent iridium anticancer complexes

Por Venkatesh, V., Berrocal-Martin, Raul, Wedge, Christopher J., Romero-Canelón, Isolda, Sanchez-Cano, Carlos, Song, Ji-Inn, Coverdale, James P. C., Zhang, Pingyu, Clarkson, Guy J., Habtemariam, Abraha, Magennis, Steven W., Deeth, Robert J., Sadler, Peter J.
Publicado no Chem Sci (2017)