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Direct β‐ and γ‐C(sp(3))−H Alkynylation of Free Carboxylic Acids

In this study we report the identification of a novel class of ligands for palladium‐catalyzed C(sp(3))−H activation that enables the direct alkynylation of free carboxylic acid substrates. In contrast to previous synthetic methods, no introduction/removal of an exogenous directing group is required...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Ghiringhelli, Francesca, Uttry, Alexander, Ghosh, Kiron Kumar, van Gemmeren, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756274/
https://ncbi.nlm.nih.gov/pubmed/32898310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202010784
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