Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling

Multiple sclerosis (MS), an autoimmune and degenerative disease, is characterized by demyelination and chronic neuroinflammation. Bixin is a carotenoid isolated from the seeds of Bixa orellana that exhibits various potent pharmacological activities, including antioxidant, anti-inflammatory, and anti...

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Опубликовано в: :Front Immunol
Главные авторы: Yu, Ye, Wu, Dong-Ming, Li, Jing, Deng, Shi-Hua, Liu, Teng, Zhang, Ting, He, Miao, Zhao, Yang-Yang, Xu, Ying
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2020
Предметы:
Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756000/
https://ncbi.nlm.nih.gov/pubmed/33362775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.593368
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