Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway

Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, has been shown to inhibit cerebral ischemic injury. However, its potential molecular action on blood-brain barrier (BBB) dysfunction after stroke remains unclear. This study aimed to investigate the effects of ruscogenin o...

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Udgivet i:Int J Mol Sci
Main Authors: Cao, Guosheng, Jiang, Nan, Hu, Yang, Zhang, Yuanyuan, Wang, Guangyun, Yin, Mingzhu, Ma, Xiaonan, Zhou, Kecheng, Qi, Jin, Yu, Boyang, Kou, Junping
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037697/
https://ncbi.nlm.nih.gov/pubmed/27589720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17091418
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