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Microtubule attachment and centromeric tension shape the protein architecture of the human kinetochore

The nanoscale protein architecture of the kinetochore, a complex protein machine, plays an integral role in the molecular mechanisms underlying its functions in chromosome segregation. However, defining this architecture in human cells remains challenging because of the large size and compositional...

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Veröffentlicht in:Curr Biol
Hauptverfasser: Kukreja, Alexander A., Kavuri, Sisira, Joglekar, Ajit. P
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755829/
https://ncbi.nlm.nih.gov/pubmed/33035484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2020.09.038
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