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Mechanical tension promotes formation of gastrulation-like nodes and patterns mesoderm specification in human embryonic stem cells

Embryogenesis is directed by morphogens that induce differentiation within a defined tissue geometry. Tissue organization is mediated by cell-cell and cell-extracellular matrix (ECM) adhesions and is modulated by cell tension and tissue-level forces. Whether cell tension regulates development by mod...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Muncie, Jonathon M., Ayad, Nadia M.E., Lakins, Johnathon N., Xue, Xufeng, Fu, Jianping, Weaver, Valerie M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755684/
https://ncbi.nlm.nih.gov/pubmed/33207224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2020.10.015
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