2-Oxaadamant-1-yl ureas as soluble epoxide hydrolase inhibitors: in vivo evaluation in a murine model of acute pancreatitis

In vivo pharmacological inhibition of soluble epoxide hydrolase (sEH) reduces inflammatory diseases, including acute pancreatitis (AP). Adamantyl ureas are very potent sEH inhibitors but the lipophilicity and metabolism of the adamantane group compromises their overall usefulness. Herein, we report...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Codony, Sandra, Pujol, Eugènia, Pizarro, Javier, Feixas, Ferran, Valverde, Elena, Loza, M. Isabel, Brea, José M., Saez, Elena, Oyarzabal, Julen, Pineda-Lucena, Antonio, Pérez, Belén, Pérez, Concepción, Rodríguez-Franco, María Isabel, Leiva, Rosana, Osuna, Sílvia, Morisseau, Christophe, Hammock, Bruce D., Vázquez-Carrera, Manuel, Vázquez, Santiago
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755424/
https://ncbi.nlm.nih.gov/pubmed/32787085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00310
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