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Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors

Soluble epoxide hydrolase (sEH) inhibitors are potential drugs for several diseases. Adamantyl ureas are excellent sEH inhibitors but have limited metabolic stability. Herein, we report the effect of replacing the adamantane group by alternative polycyclic hydrocarbons on sEH inhibition, solubility,...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Codony, Sandra, Valverde, Elena, Leiva, Rosana, Brea, José, Loza, M. Isabel, Morisseau, Christophe, Hammock, Bruce D., Vázquez, Santiago
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892585/
https://ncbi.nlm.nih.gov/pubmed/31488357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.115078
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