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Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors
Soluble epoxide hydrolase (sEH) inhibitors are potential drugs for several diseases. Adamantyl ureas are excellent sEH inhibitors but have limited metabolic stability. Herein, we report the effect of replacing the adamantane group by alternative polycyclic hydrocarbons on sEH inhibition, solubility,...
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| Publicat a: | Bioorg Med Chem |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6892585/ https://ncbi.nlm.nih.gov/pubmed/31488357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.115078 |
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