Catalytic Promiscuity of cGAS: A Facile Enzymatic Synthesis of 2′‐3′‐Linked Cyclic Dinucleotides

Cyclic GMP‐AMP synthase (cGAS) is a cytosolic DNA sensor that catalyzes the synthesis of the cyclic GMP‐AMP dinucleotide 2′3′‐cGAMP. 2′3′‐cGAMP functions as inducer for the production of type I interferons. Derivatives of this important second messenger are highly valuable for pharmaceutical applica...

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Vydáno v:Chembiochem
Hlavní autoři: Rosenthal, Katrin, Becker, Martin, Rolf, Jascha, Siedentop, Regine, Hillen, Michael, Nett, Markus, Lütz, Stephan
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754487/
https://ncbi.nlm.nih.gov/pubmed/32633874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000433
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