Pharmacokinetics and Pharmacodynamics of Subcutaneous Sarilumab and Intravenous Tocilizumab Following Single‐Dose Administration in Patients With Active Rheumatoid Arthritis on Stable Methotrexate

We assessed pharmacokinetics (PK), pharmacodynamics (PD), and PK/PD relationships of interleukin‐6 (IL‐6), soluble IL‐6 receptor, and C‐reactive protein (CRP) in serum, and absolute neutrophil count (ANC) in blood following single doses of subcutaneous sarilumab versus intravenous tocilizumab (NCT02...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Clin Pharmacol
Egile Nagusiak: Paccaly, Anne J., Kovalenko, Pavel, Parrino, Janie, Boyapati, Anita, Xu, Christine, van Hoogstraten, Hubert, Ishii, Tomonori, Davis, John D., DiCioccio, A. Thomas
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2020
Gaiak:
Pharmacokinetics/Pharmacodynamics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754484/
https://ncbi.nlm.nih.gov/pubmed/32726514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1703
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