Population Pharmacodynamic Model of Neutrophil Margination and Tolerance to Describe Effect of Sarilumab on Absolute Neutrophil Count in Patients with Rheumatoid Arthritis

Evidence suggests that effects of interleukin‐6 pathway inhibitors sarilumab, tocilizumab, and sirukumab on absolute neutrophil count (ANC) are due to margination of circulating neutrophils into rapidly mobilizable noncirculating pools. We developed a population pharmacodynamic model using compartme...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:CPT Pharmacometrics Syst Pharmacol
Hoofdauteurs: Kovalenko, Pavel, Paccaly, Anne, Boyapati, Anita, Xu, Christine, St John, Gregory, Nivens, Michael C., Davis, John D., Rippley, Ronda, DiCioccio, A. Thomas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2020
Onderwerpen:
Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7376291/
https://ncbi.nlm.nih.gov/pubmed/32453485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12534
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items