Population Pharmacodynamic Model of Neutrophil Margination and Tolerance to Describe Effect of Sarilumab on Absolute Neutrophil Count in Patients with Rheumatoid Arthritis

Evidence suggests that effects of interleukin‐6 pathway inhibitors sarilumab, tocilizumab, and sirukumab on absolute neutrophil count (ANC) are due to margination of circulating neutrophils into rapidly mobilizable noncirculating pools. We developed a population pharmacodynamic model using compartme...

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Detalles Bibliográficos
Publicado en:CPT Pharmacometrics Syst Pharmacol
Main Authors: Kovalenko, Pavel, Paccaly, Anne, Boyapati, Anita, Xu, Christine, St John, Gregory, Nivens, Michael C., Davis, John D., Rippley, Ronda, DiCioccio, A. Thomas
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7376291/
https://ncbi.nlm.nih.gov/pubmed/32453485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12534
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