Population Pharmacodynamic Model of Neutrophil Margination and Tolerance to Describe Effect of Sarilumab on Absolute Neutrophil Count in Patients with Rheumatoid Arthritis

Evidence suggests that effects of interleukin‐6 pathway inhibitors sarilumab, tocilizumab, and sirukumab on absolute neutrophil count (ANC) are due to margination of circulating neutrophils into rapidly mobilizable noncirculating pools. We developed a population pharmacodynamic model using compartme...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:CPT Pharmacometrics Syst Pharmacol
Egile Nagusiak: Kovalenko, Pavel, Paccaly, Anne, Boyapati, Anita, Xu, Christine, St John, Gregory, Nivens, Michael C., Davis, John D., Rippley, Ronda, DiCioccio, A. Thomas
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2020
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7376291/
https://ncbi.nlm.nih.gov/pubmed/32453485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12534
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