Amino Acid Catalyzed Direct Aldol Bioconjugation

A site-specific bioconjugation was developed based on direct aldol coupling using amino acid-derived organocatalysts. The functionalization exhibits fast kinetics and occurs under mild, biocompatible conditions (viz., aqueous media, moderate temperature, and neutral pH). The resulting bioconjugates...

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Bibliographic Details
Published in:Org Lett
Main Authors: Howard, Tiauna S., Cohen, Ryan D., Nwajiobi, Ogonna, Muneeswaran, Zilma P., Sim, Yonnette E., Lahankar, Neelam N., Yeh, Johannes, Raj, Monika
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7751349/
https://ncbi.nlm.nih.gov/pubmed/30125118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.8b02265
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