Punicalagin Inhibits Tert-Butyl Hydroperoxide-Induced Apoptosis and Extracellular Matrix Degradation in Chondrocytes by Activating Autophagy and Ameliorates Murine Osteoarthritis

BACKGROUND: Osteoarthritis (OA) is a prevalent articular disorder and has no entirely satisfactory treatment. Punicalagin (PUG) is a polyphenol which has shown multiple pharmacological effects on various diseases. However, the role of PUG in the treatment of OA has not been well defined. METHODS: Th...

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Vydáno v:Drug Des Devel Ther
Hlavní autoři: Kong, Jinsong, Wang, Jiacheng, Gong, Xiaokang, Zheng, Xin, Chen, Tao
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove 2020
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7751323/
https://ncbi.nlm.nih.gov/pubmed/33364748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S282932
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