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Altering the Neisseria gonorrhoeae pilE guanine quadruplex loop bases affects pilin antigenic variation

Neisseria gonorrhoeae possesses a programmed recombination system that allows the bacteria to alter the major subunit of the type IV pilus, pilin or PilE. An alternate DNA structure known as a guanine quadruplex (G4) is required for pilin antigenic variation (pilin Av). The G-C base pairs within the...

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Bibliographic Details
Published in:Biochemistry
Main Authors: Prister, Lauren L., Yin, Shaohui, Cahoon, Laty A., Seifert, H Steven
Format: Artigo
Language:Inglês
Published: 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7750920/
https://ncbi.nlm.nih.gov/pubmed/32078293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b01038
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