Neisseria gonorrhoeae RecQ Helicase HRDC Domains Are Essential for Efficient Binding and Unwinding of the pilE Guanine Quartet Structure Required for Pilin Antigenic Variation

The strict human pathogen Neisseria gonorrhoeae utilizes homologous recombination to antigenically vary the pilus, thus evading the host immune response. High-frequency gene conversion reactions between many silent pilin loci and the expressed pilin locus (pilE) allow for numerous pilus variants per...

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Hauptverfasser: Cahoon, Laty A., Manthei, Kelly A., Rotman, Ella, Keck, James L., Seifert, H. Steven
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650551/
https://ncbi.nlm.nih.gov/pubmed/23475972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.02217-12
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