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Genetic background influences the impact of KLOTHO deficiency

Genetic background is a key but sometimes overlooked factor that profoundly impacts disease susceptibility and presentation in both humans and disease models. Here we show that deficiency of KLOTHO protein, an important renal regulator of mineral homeostasis and a cofactor for FGF23, causes differen...

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Vydáno v:Physiol Genomics
Hlavní autoři: Salloum, Jawad S., Garsetti, Diane E., Rogers, Melissa B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7750509/
https://ncbi.nlm.nih.gov/pubmed/32956023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00094.2020
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