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Genetic background influences the impact of KLOTHO deficiency

Genetic background is a key but sometimes overlooked factor that profoundly impacts disease susceptibility and presentation in both humans and disease models. Here we show that deficiency of KLOTHO protein, an important renal regulator of mineral homeostasis and a cofactor for FGF23, causes differen...

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Publicado en:Physiol Genomics
Autores principales: Salloum, Jawad S., Garsetti, Diane E., Rogers, Melissa B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7750509/
https://ncbi.nlm.nih.gov/pubmed/32956023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00094.2020
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