Essentially Leading Antibody Production: An Investigation of Amino Acids, Myeloma, and Natural V-Region Signal Peptides in Producing Pertuzumab and Trastuzumab Variants

Boosting the production of recombinant therapeutic antibodies is crucial in both academic and industry settings. In this work, we investigated the usage of varying signal peptides by antibody V-genes and their roles in recombinant transient production, systematically comparing myeloma and the native...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Ling, Wei-Li, Su, Chinh Tran-To, Lua, Wai-Heng, Poh, Jun-Jie, Ng, Yuen-Ling, Wipat, Anil, Gan, Samuel Ken-En
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7750424/
https://ncbi.nlm.nih.gov/pubmed/33365032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.604318
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