Effect of VH–VL Families in Pertuzumab and Trastuzumab Recombinant Production, Her2 and FcγIIA Binding

Many therapeutic antibodies are humanized from animal sources. In the humanization process, complementarity determining region grafting is tedious and highly prone to failure. With seven known VH families, and up to six known κ VL families, there are choices aplenty. However, the functions of these...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Immunol
Prif Awduron: Ling, Wei-Li, Lua, Wai-Heng, Poh, Jun-Jie, Yeo, Joshua Yi, Lane, David Philip, Gan, Samuel Ken-En
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2018
Pynciau:
Immunology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857972/
https://ncbi.nlm.nih.gov/pubmed/29593727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00469
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