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Determining homologous recombination deficiency scores with whole exome sequencing and their association with responses to neoadjuvant chemotherapy in breast cancer

Recent studies demonstrated that homologous repair deficiency (HRD) score is a useful marker for response to poly (ADP-ribose) polymerase inhibitors or platinum-based chemotherapy. We determined HRD scores and elucidated the clinicopathologic characteristics of HRD-high tumors and their response to...

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Veröffentlicht in:Transl Oncol
Hauptverfasser: Kim, Seung Jin, Sota, Yoshiaki, Naoi, Yasuto, Honma, Keiichiro, Kagara, Naofumi, Miyake, Tomohiro, Shimoda, Masafumi, Tanei, Tomonori, Seno, Shigeto, Matsuda, Hideo, Noguchi, Shinzaburo, Shimazu, Kenzo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press 2020
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7750421/
https://ncbi.nlm.nih.gov/pubmed/33340887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100986
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