The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer’s disease

Numerous studies demonstrate that neuroinflammation is a key player in the progression of Alzheimer’s disease (AD). Interleukin (IL)-1β is a main inducer of inflammation and therefore a prime target for therapeutic options. The inactive IL-1β precursor requires processing by the the nucleotide-bindi...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Lonnemann, Niklas, Hosseini, Shirin, Marchetti, Carlo, Skouras, Damaris B., Stefanoni, Davide, D’Alessandro, Angelo, Dinarello, Charles A., Korte, Martin
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2020
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749353/
https://ncbi.nlm.nih.gov/pubmed/33257576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2009680117
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