OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation

Activation of the NLRP3 inflammasome induces maturation of IL-1β and IL-18, both validated targets for treating acute and chronic inflammatory diseases. Here, we demonstrate that OLT1177, an orally active β-sulfonyl nitrile molecule, inhibits activation of the NLRP3 inflammasome. In vitro, nanomolar...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Marchetti, Carlo, Swartzwelter, Benjamin, Gamboni, Fabia, Neff, Charles P., Richter, Katrin, Azam, Tania, Carta, Sonia, Tengesdal, Isak, Nemkov, Travis, D’Alessandro, Angelo, Henry, Curtis, Jones, Gerald S., Goodrich, Scott A., St. Laurent, Joseph P., Jones, Terry M., Scribner, Curtis L., Barrow, Robert B., Altman, Roy D., Skouras, Damaris B., Gattorno, Marco, Grau, Veronika, Janciauskiene, Sabina, Rubartelli, Anna, Joosten, Leo A. B., Dinarello, Charles A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816172/
https://ncbi.nlm.nih.gov/pubmed/29378952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716095115
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