OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation

Activation of the NLRP3 inflammasome induces maturation of IL-1β and IL-18, both validated targets for treating acute and chronic inflammatory diseases. Here, we demonstrate that OLT1177, an orally active β-sulfonyl nitrile molecule, inhibits activation of the NLRP3 inflammasome. In vitro, nanomolar...

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Marchetti, Carlo, Swartzwelter, Benjamin, Gamboni, Fabia, Neff, Charles P., Richter, Katrin, Azam, Tania, Carta, Sonia, Tengesdal, Isak, Nemkov, Travis, D’Alessandro, Angelo, Henry, Curtis, Jones, Gerald S., Goodrich, Scott A., St. Laurent, Joseph P., Jones, Terry M., Scribner, Curtis L., Barrow, Robert B., Altman, Roy D., Skouras, Damaris B., Gattorno, Marco, Grau, Veronika, Janciauskiene, Sabina, Rubartelli, Anna, Joosten, Leo A. B., Dinarello, Charles A.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2018
主題:
PNAS Plus
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816172/
https://ncbi.nlm.nih.gov/pubmed/29378952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716095115
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