OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation

Activation of the NLRP3 inflammasome induces maturation of IL-1β and IL-18, both validated targets for treating acute and chronic inflammatory diseases. Here, we demonstrate that OLT1177, an orally active β-sulfonyl nitrile molecule, inhibits activation of the NLRP3 inflammasome. In vitro, nanomolar...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Marchetti, Carlo, Swartzwelter, Benjamin, Gamboni, Fabia, Neff, Charles P., Richter, Katrin, Azam, Tania, Carta, Sonia, Tengesdal, Isak, Nemkov, Travis, D’Alessandro, Angelo, Henry, Curtis, Jones, Gerald S., Goodrich, Scott A., St. Laurent, Joseph P., Jones, Terry M., Scribner, Curtis L., Barrow, Robert B., Altman, Roy D., Skouras, Damaris B., Gattorno, Marco, Grau, Veronika, Janciauskiene, Sabina, Rubartelli, Anna, Joosten, Leo A. B., Dinarello, Charles A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816172/
https://ncbi.nlm.nih.gov/pubmed/29378952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716095115
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