Pre-steady-state Kinetic Studies Establish Entecavir 5′-Triphosphate as a Substrate for HIV-1 Reverse Transcriptase

The novel 2′-deoxyguanosine analog Entecavir (ETV) is a potent inhibitor of hepatitis B virus (HBV) replication and is recommended for treatment in human immunodeficiency virus type 1 (HIV-1) and HBV-co-infected patients because it had been reported that ETV is HBV-specific. Recent clinical observat...

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Publicado no:J Biol Chem
Main Authors: Domaoal, Robert A., McMahon, Moira, Thio, Chloe L., Bailey, Christopher M., Tirado-Rives, Julian, Obikhod, Aleksander, Detorio, Mervi, Rapp, Kimberly L., Siliciano, Robert F., Schinazi, Raymond F., Anderson, Karen S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7748947/
https://ncbi.nlm.nih.gov/pubmed/17962184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707834200
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