The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells

Phosphoenolpyruvate carboxykinase (PEPCK) is a gluconeogenic enzyme with a cytosolic (Pck1/PEPCK-C) and mitochondrial (Pck2/PEPCK-M) isoform. Here we investigate the effect of 3-mercaptopicolinic acid (3-MPA), a PEPCK inhibitor, on C2C12 muscle cells. We report that Pck2 mRNA is 50–5000-fold higher...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Brearley, Madelaine C., Daniel, Zoe C. T. R., Loughna, Paul T., Parr, Tim, Brameld, John M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7747743/
https://ncbi.nlm.nih.gov/pubmed/33335245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79324-9
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