IL4I1 Accelerates the Expansion of Effector CD8(+) T Cells at the Expense of Memory Precursors by Increasing the Threshold of T-Cell Activation

IL4I1 is an immunoregulatory enzyme that inhibits CD8 T-cell proliferation in vitro and in the tumoral context. Here, we dissected the effect of IL4I1 on CD8 T-cell priming by studying the differentiation of a transgenic CD8 T-cell clone and the endogenous repertoire in a mouse model of acute lympho...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Puiffe, Marie-Line, Dupont, Aurélie, Sako, Nouhoum, Gatineau, Jérôme, Cohen, José L., Mestivier, Denis, Lebon, Agnès, Prévost-Blondel, Armelle, Castellano, Flavia, Molinier-Frenkel, Valérie
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7746639/
https://ncbi.nlm.nih.gov/pubmed/33343572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.600012
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