Transcriptomic and proteomic intra-tumor heterogeneity of colorectal cancer varies depending on tumor location within the colorectum

BACKGROUND: Intra-tumor heterogeneity (ITH) of colorectal cancer (CRC) complicates molecular tumor classification, such as transcriptional subtyping. Differences in cellular states, biopsy cell composition, and tumor microenvironment may all lead to ITH. Here we analyze ITH at the transcriptomic and...

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Bibliographic Details
Published in:PLoS One
Main Authors: Árnadóttir, Sigrid Salling, Mattesen, Trine Block, Vang, Søren, Madsen, Mogens Rørbæk, Madsen, Anders Husted, Birkbak, Nicolai Juul, Bramsen, Jesper Bertram, Andersen, Claus Lindbjerg
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7746197/
https://ncbi.nlm.nih.gov/pubmed/33332369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0241148
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