Characterization of genetic intratumor heterogeneity in colorectal cancer and matching patient‐derived spheroid cultures

Patient‐derived in vitro cultures of colorectal cancer (CRC) may help guide treatment strategies prior to patient treatment. However, most previous studies have been performed on a single biopsy per tumor. The purpose of this study was to analyze multiple spatially distinct biopsies from CRCs and se...

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Main Authors: Sigrid S. Árnadóttir, Maria Jeppesen, Philippe Lamy, Jesper B. Bramsen, Iver Nordentoft, Michael Knudsen, Søren Vang, Mogens R. Madsen, Ole Thastrup, Jacob Thastrup, Claus L. Andersen
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2018-01-01
Serier:Molecular Oncology
Fag:
colorectal cancer
intratumor heterogeneity
patient‐derived spheroid cultures
whole exome sequencing
Online adgang:https://doi.org/10.1002/1878-0261.12156
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