Mechanisms of proton inhibition and sensitization of the cation channel TRPV3

TRPV3 is a temperature-sensitive, nonselective cation channel expressed prominently in skin keratinocytes. TRPV3 plays important roles in hair morphogenesis and maintenance of epidermal barrier function. Gain-of-function mutations of TRPV3 have been found in both humans and rodents and are associate...

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Veröffentlicht in:J Gen Physiol
Hauptverfasser: Wang, Haiyuan, Yang, Pu, Lu, Yungang, Wang, Jin, Jeon, Jaepyo, Wang, Qiaochu, Tian, Jin-Bin, Zang, Bin, Yu, Ye, Zhu, Michael X.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Rockefeller University Press 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7745752/
https://ncbi.nlm.nih.gov/pubmed/33320167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.202012663
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