Pain Modulation in WAG/Rij Epileptic Rats (A Genetic Model of Absence Epilepsy): Effects of Biological and Pharmacological Histone Deacetylase Inhibitors

Epigenetic mechanisms are involved in epilepsy and chronic pain development. About that, we studied the effects of the natural histone deacetylase (HDAC) inhibitor sodium butyrate (BUT) in comparison with valproic acid (VPA) in a validated genetic model of generalized absence epilepsy and epileptoge...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: De Caro, Carmen, Di Cesare Mannelli, Lorenzo, Branca, Jacopo Junio Valerio, Micheli, Laura, Citraro, Rita, Russo, Emilio, De Sarro, Giovambattista, Ghelardini, Carla, Calignano, Antonio, Russo, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7745735/
https://ncbi.nlm.nih.gov/pubmed/33343343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.549191
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