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Effects of Excipients on the Structure and Dynamics of Filgrastim Monitored by Thermal Unfolding Studies by CD and NMR Spectroscopy

[Image: see text] Product excipients are used to confer a number of desirable properties on the drug substance to maintain or improve stability and facilitate drug delivery. This is especially important for products where the active pharmaceutical ingredient (API) is a recombinant protein. In this s...

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Foilsithe in:ACS Omega
Main Authors: Ghasriani, Houman, Frahm, Grant E., Johnston, Michael J. W., Aubin, Yves
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2020
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7745408/
https://ncbi.nlm.nih.gov/pubmed/33344838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.0c04692
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