Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation

UDP-glucuronosyltransferase (UGT) 1A1 is the only transferase capable of conjugating serum bilirubin. However, temporal delay in the development of the UGT1A1 gene leads to an accumulation of serum bilirubin in newborn children. Neonatal humanized UGT1 (hUGT1) mice, which accumulate severe levels of...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Weber, André A., Mennillo, Elvira, Yang, Xiaojing, van der Schoor, Lori W.E., Jonker, Johan W., Chen, Shujuan, Tukey, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2021
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7745083/
https://ncbi.nlm.nih.gov/pubmed/33154041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.120.000240
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