Gain-of-function hot spot mutant p53(R248Q) regulation of integrin/FAK/ERK signaling in esophageal squamous cell carcinoma

PURPOSE: TP53, encoding the protein p53, is among the most frequently mutated genes in all cancers. A high frequency of 60 – 90% mutations is seen in esophageal squamous cell carcinoma (ESCC) patients. Certain p53 mutants show gain-of-function (GoF) oncogenic features unrelated to its wild type func...

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Vydáno v:Transl Oncol
Hlavní autoři: Yu, Valen Zhuoyou, So, Shan Shan, Lung, Maria Li
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press 2020
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744772/
https://ncbi.nlm.nih.gov/pubmed/33395748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100982
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