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Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis
Mutant p53 proteins not only lose their tumor-suppressor function but some acquire oncogenic gain of function (GOF). The published mutp53 knock-in (KI) alleles (R172H, R270H, R248W) manifest GOF by broader tumor spectrum and more metastasis compared with the p53-null allele, but do not shorten survi...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3679454/ https://ncbi.nlm.nih.gov/pubmed/23538418 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.17 |
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