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Diverse and cancer type-specific roles of the p53 R248Q gain-of-function mutation in cancer migration and invasiveness
Gain-of-function (GOF) mutations in the TP53 gene lead to acquisition of new functions by the mutated tumor suppressor p53 protein. A number of the over-represented ‘hot spot’ mutations, including the ones in codons 175, 248 or 273, convey GOF phenotypes. Such phenotypes may include resistance to ch...
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| Publicado no: | Int J Oncol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
D.A. Spandidos
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6411346/ https://ncbi.nlm.nih.gov/pubmed/30968154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2019.4723 |
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