Imaging Neurochemistry and Brain Structure Tracks Clinical Decline and Mechanisms of ALS in Patients

Background: Oxidative stress and protein aggregation are key mechanisms in amyotrophic lateral sclerosis (ALS) disease. Reduced glutathione (GSH) is the most important intracellular antioxidant that protects neurons from reactive oxygen species. We hypothesized that levels of GSH measured by MR spec...

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Pubblicato in:Front Neurol
Autori principali: Andronesi, Ovidiu C., Nicholson, Katharine, Jafari-Khouzani, Kourosh, Bogner, Wolfgang, Wang, Jing, Chan, James, Macklin, Eric A., Levine-Weinberg, Mark, Breen, Christopher, Schwarzschild, Michael A., Cudkowicz, Merit, Rosen, Bruce R., Paganoni, Sabrina, Ratai, Eva-Maria
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Neurology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744722/
https://ncbi.nlm.nih.gov/pubmed/33343494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2020.590573
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