Imaging Neurochemistry and Brain Structure Tracks Clinical Decline and Mechanisms of ALS in Patients

Background: Oxidative stress and protein aggregation are key mechanisms in amyotrophic lateral sclerosis (ALS) disease. Reduced glutathione (GSH) is the most important intracellular antioxidant that protects neurons from reactive oxygen species. We hypothesized that levels of GSH measured by MR spec...

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Detalhes bibliográficos
Publicado no:Front Neurol
Main Authors: Andronesi, Ovidiu C., Nicholson, Katharine, Jafari-Khouzani, Kourosh, Bogner, Wolfgang, Wang, Jing, Chan, James, Macklin, Eric A., Levine-Weinberg, Mark, Breen, Christopher, Schwarzschild, Michael A., Cudkowicz, Merit, Rosen, Bruce R., Paganoni, Sabrina, Ratai, Eva-Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Neurology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744722/
https://ncbi.nlm.nih.gov/pubmed/33343494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2020.590573
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