Pilot trial of inosine to elevate urate levels in amyotrophic lateral sclerosis

OBJECTIVE: To test the safety, tolerability, and urate‐elevating capability of the urate precursor inosine taken orally or by feeding tube in people with amyotrophic lateral sclerosis (ALS). METHODS: This was a pilot, open‐label trial in 25 participants with ALS. Treatment duration was 12 weeks. The...

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Detaylı Bibliyografya
Yayımlandı:Ann Clin Transl Neurol
Asıl Yazarlar: Nicholson, Katharine, Chan, James, Macklin, Eric A., Levine‐Weinberg, Mark, Breen, Christopher, Bakshi, Rachit, Grasso, Daniela L., Wills, Anne‐Marie, Jahandideh, Samad, Taylor, Albert A., Beaulieu, Danielle, Ennist, David L., Andronesi, Ovidiu, Ratai, Eva‐Maria, Schwarzschild, Michael A., Cudkowicz, Merit, Paganoni, Sabrina
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2018
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6292193/
https://ncbi.nlm.nih.gov/pubmed/30564619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.671
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