Pilot trial of inosine to elevate urate levels in amyotrophic lateral sclerosis

OBJECTIVE: To test the safety, tolerability, and urate‐elevating capability of the urate precursor inosine taken orally or by feeding tube in people with amyotrophic lateral sclerosis (ALS). METHODS: This was a pilot, open‐label trial in 25 participants with ALS. Treatment duration was 12 weeks. The...

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Pubblicato in:Ann Clin Transl Neurol
Autori principali: Nicholson, Katharine, Chan, James, Macklin, Eric A., Levine‐Weinberg, Mark, Breen, Christopher, Bakshi, Rachit, Grasso, Daniela L., Wills, Anne‐Marie, Jahandideh, Samad, Taylor, Albert A., Beaulieu, Danielle, Ennist, David L., Andronesi, Ovidiu, Ratai, Eva‐Maria, Schwarzschild, Michael A., Cudkowicz, Merit, Paganoni, Sabrina
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6292193/
https://ncbi.nlm.nih.gov/pubmed/30564619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.671
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